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It was discovered that naltrexone and bupropion combined, that could be marketed down the road as Contrave, give better weight loss results than exercise and dieting alone.

Using two separate drugs to lose weight can be very effective you will find combinations as you're watching FDA now awaiting approval. When dealing with weight reduction and the those who go through it you need to err to the side of caution and allow FDA do its job and demand some study be done so that the public recognizes the side effects and perils associated with the medications before we take them. Keep in mind that drug companies have been in business to generate money and that they would say everything to keep people on their own medications.

Researchers discovered that participants taking this drug for a year, dropped a few pounds within four weeks and have kept the weight off through the entire 56 weeks with the study. Contrave is often a combination with the drugs naltrexone and bupropion, which generally seems to reflect a new trend of weight-loss drugs which might be made up of several active ingredient, that might make them more efficient and safer.

Combo-pilling may be the newest fad or in addition to this the newest to come under scrutiny and thus it is just more publicly known recently, comb-pilling for weight loss has been around since the eighties. The biggest reason that by using a combination of pills is starting to become popular is the fact that since right now there are not any long term prescription diet pills that have been approved by the FDA other than orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications however some of the combinations happen to be rejected or have yet to be licensed by the FDA.

Seizures are a side effect with Contrave and mustn't be taken in people who have seizure disorders. The drug may also raise hypertension and heart rate, and mustn't be used in people who have a history of cardiac arrest or stroke in the last six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy using the drug.

The FDA also warned that Contrave can raise blood pressure levels and pulse rate and must stop used in patients with uncontrolled high blood pressure, along with by you are not heart-related and cerebrovascular (circulation system dysfunction impacting mental performance) disease. Patients with a history of heart attack or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes using a boxed warning to alert medical professionals and patients for the increased probability of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for stop smoking.


Most of the combinations which are used to enhance weight reduction involve an amphetamine with an antidepressant. Phentermine and Prozac certainly are a popular combination that were around for a while, although it has been around no one wants to truly combine both the and try to get FDA approval to showcase it as a fat loss pill. Right there should raise some warning flags if the greedy pharmaceutical companies don't want to be involved in combining medications and selling them something should be wrong with all the combination. In fairness there is certainly one weight-loss combination pill that is certainly in front of the FDA now Contrave?which couples naltrexone, accustomed to treat alcohol and drug addiction, with the antidepressant bupropion (Wellbutrin, Zyban) it has been given the go ahead to move forward by an FDA advisory committee, but since yet has not been approved.